mutagenetix.utsouthwestern.eduMutagenetix - Phenotypic Mutations Database

MutagenetixHome Home Home Phenotypic Mutations Incidental Mutations Engineered Mutations Candidate Explorer Protocols Mutation Statistics About Contact Links Request Mice Beutler Lab Australian Phenomics Strains @ MMRRC Search Phenotypes FEATURED Candidate Explorer Staff Login Download Phenotypic Mutations Incidental Mutations Protocols FAQs Mutation Statistics Request Mice To date, a total of … mutations in … genes have been declared causative of … instances of phenotype, based on a total of … assays of phenotype, testing the effects of … ENU-induced coding/splicing mutations. We display phenotypic data on … mutation-phenotype associations, caused by … distinct alleles of … genes. … of these records have the Candidate Status Good” or Excellent,” implying a high likelihood of verification by gene retargeting. These data may be searched, sorted, and viewed using the Candidate Explorer utility. Mutagenesis Statistics (cumulative numbers since Apr 11, 2001) G1 Mice Produced 48,185 G3 Mice Produced 310,090 Pedigrees Produced 15,601 2024-05-14 Contributing Centers Beutler Lab Australian Phenomics Network To cite Mutagenetix in a journal article or on-line publication, please use the following conventions: {Authors, Science Writers, Beutler B}. Record for {allele name}, updated {date of last update}. MUTAGENETIX (TM), B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX. Accessed {date of download}. URL: https://mutagenetix.utsouthwestern.edu . Also cite: Wang T, Bu CH, Hildebrand S, Jia G, Siggs OM, Lyon S, Pratt D, Scott L, Russell J, Ludwig S, Murray AR, Moresco EMY, Beutler B., Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database. Nat Commun. 2018 Jan 30;9(1):441. PMID: 29382827 Wang, T., et al. , Real-time resolution of point mutations that cause phenovariance in mice. Proc. Natl. Acad. Sci.U.S.A. 112(5) , E440-9 (2015). ©...